cis-Selective synthesis of 2,5-disubstituted pyrrolidines |
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| Authors: | Syed Raziullah Hussaini |
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| Institution: | The Department of Chemistry, Dyson Perrins Laboratory, The University of Oxford, South Parks Road, Oxford OX1 3QY, UK |
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| Abstract: | A concise approach to cis-2,5-disubstituted pyrrolidines is reported, which relies upon N-tert-butoxycarbonylmethyl substitution in a substrate derived from pyroglutamic acid. The method is especially noteworthy since a significant improvement in the conditions for a key Lawesson’s reaction have been established. Regioselective enolate generation and alkylation permits extension of the C-5 side chain. |
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| Keywords: | Pyrrolidines Thionation Lawesson&rsquo s reagent |
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