New possibilities of 1,2,4-triazines functionalization: first examples of synthesis and structure of boron-containing 1,2,4-triazines |
| |
| Authors: | Yuri Azev Enno Lork Detlef Gabel |
| |
| Affiliation: | a Department of Chemistry, University of Bremen, D-28334 Bremen, Germany
b Ural Scientific Research Institute of Technology of Medicinal Preparations, 620219 Ekaterinburg, Russian Federation |
| |
| Abstract: | By oxidation of 3-thioderivatives of 1,2,4-triazine 1a,b 3-alkylsulfonic derivatives 2a,b were obtained. Interaction of the sulfonic derivative 2a with indole leads to 3-oxo-5-indolyl-5-phenyl-as-triazine 4. The sulfone 2a reacts with 1-ethyl-2,6-dimethylquinolinium iodide to give 3-(1-ethyl-6-methyl-1,2-dihydroquinoline-2-methylene)-5-phenyl-1,2,4-triazine 5. The 3-morpholino- 3 and 3-thioderivatives 6, 7a,b of as-triazine were obtained by interaction of the sulfone 2 with morpholine and organic boron-containing thiols. The crystal structure of boron-containing derivative of as-triazine 7b was investigated by X-ray analysis. |
| |
| Keywords: | Triazine Boranes Boron neutron capture therapy Mass spectrometry |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
