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Efficient preparation of carbohydrate- and related polyol-amphiphiles by hydrazone ligation |
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| Authors: | Cyrille Grandjean Valérie Santraine Ange Polidori Hélène Gras-Masse Dominique Bonnet |
| Institution: | a SEDAC-Therapeutics, Parc Eurasanté, Le Galénis, 85, rue Nelson Mandela, 59120 Loos, France b Laboratoire de Chimie Bioorganique et des Systèmes Moléculaires Vectoriels, Faculté des Sciences, Université d'Avignon, 33, rue Louis Pasteur, 84000 Avignon, France c UMR CNRS 8525, Institut de Biologie de Lille, 1, rue du Pr Calmette, 59000 Lille, France |
| Abstract: | The hydrazone ligation can be used to couple clustered-glycosides or glycomimetics functionalized with a hydrazino group with lipophilic glyoxylyl acid derivatives to give the corresponding amphiphiles in high yield and purity. |
| Keywords: | Carbohydrate Amphiphile Chemoselective ligation |
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