A simple, two-step synthesis of 3-iodoindoles |
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| Authors: | Muhammad Amjad |
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| Institution: | Cardiff School of Chemistry, Cardiff University, PO Box 912, Cardiff CF10 3TB, UK |
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| Abstract: | 2-Halo-anilines, protected as the corresponding sulfonamides or carbamates, can be converted very efficiently into 3-iodoindoles by sequential Sonogashira coupling with a 1-alkyne and 5-endo-dig iodocyclisation. Azaindoles can also be obtained using this methodology. |
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| Keywords: | 5-Endo-dig Iodocyclisation Sonogashira Indole Synthesis |
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