Liquid phase synthesis of chiral quinoxalinones by microwave irradiation |
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| Authors: | Chieh-Li Tung |
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| Institution: | Laboratory of Combinatorial Drug Discovery, National Dong Hwa University, Shou-Feng, Hualien 974, Taiwan |
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| Abstract: | Single mode microwave-assisted combinatorial synthesis of biologically interesting quinoxalinones is described. Chiral libraries of quinoxalinone were readily assembled utilizing SNAr reactions, reduction and followed with concomitant cyclization under microwave irradiation. Enantiomeric 1,2,3,4-tetrahydroquinoxalinones were isolated in excellent yield and purity after cleavage. |
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