A synthesis of camptothecin |
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| Authors: | Subhash P. Chavan Rasapalli Sivappa |
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| Affiliation: | Division of Organic Chemistry: Technology, National Chemical Laboratory, Pune 411008, India |
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| Abstract: | A total synthesis of camptothecin has been carried out. Central to our synthesis is the intramolecular condensation of a suitably designed ketol, which in turn was obtained from a tricyclic ABC ring synthon. A tandem reductive amination and Michael addition sequence on an unsaturated quinoline ester was employed for the assembly of the ABC skeleton. |
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| Keywords: | Camptothecin Total synthesis Tandem reductive amination-Michael addition Ketol |
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