首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Efficient synthesis of core 2 class glycosyl amino acids by one-pot glycosylation approach
Authors:Hiroshi Tanaka
Institution:Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro, Tokyo 152-8552, Japan
Abstract:We describe the one-pot synthesis of core 2 class branched oligosaccharides initiated by chemo-selective glycosylation of silyl ether. Glycosylation of 6-O-silyl-4-benzyl-2-azido-thiogalactoside with glycosyl fluoride provided selectively 6-glycosylated thioglycoside without both O-glycosylation at the 3 position and S-glycosylation. Subsequent coupling of galactosyl fluoride and amino acids afforded the protected branched oligosaccharides in good yields.
Keywords:Glycosyl amino acids  One-pot glycosylation  Glycopeptides  Glycosyl fluorides  Oligosaccharide
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号