One-pot synthesis of α-bromoesters and ketones from β-ketoesters and diketones using supported reagents system |
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| Authors: | Tadashi Aoyama Toshio Takido |
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| Institution: | a Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan
b Department of Applied Chemistry, Shibaura Institute of Technology, Shibaura, Minato-ku, Tokyo 108-8548, Japan |
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| Abstract: | A simple and efficient method has been developed for the synthesis of α-bromoesters and ketones from β-ketoesters and diketones in one pot using a supported reagents system, CuBr2/Al2O3-Na2CO3/Al2O3, in which β-ketoester reacts first with CuBr2/Al2O3 and the product, α-bromo-β-ketoester, reacts with Na2CO3/Al2O3 to give the final product, α-bromoesters in good yields. |
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