Two novel 3,4-seco-trinorlanostane triterpenoids isolated from Ganoderma fornicatum |
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| Authors: | Xuemei Niu Minghua Qiu Zhongrong Li Peng Cao |
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| Institution: | a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China
b Institute of Materia Medica, The Chinese Academy of Sciences, Beijing 100050, PR China |
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| Abstract: | Two novel 3,4-seco-25,26,27-trinorlanostane triterpeniod compounds, fornicatins A and B (1 and 2) have been isolated from the fruiting body of G. fornicatum. The structural elucidation of 1 and 2 were accomplished by extensive NMR analysis. The relative stereochemistry of 2 was established by single crystal X-ray crystallography, which also confirmed the novel carbon skeleton of the new triterpenoid. An ether linkage of C-4 with C-7 in 1 is unprecedented in natural triterpenoids. Both compounds were tested for their inhibitory effects on rabbit platelet aggregation induced by PAF, ADP, or AA. |
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| Keywords: | Ganoderma fornicatum Ganodermataceae Trinorlanostane Fornicatins A and B NMR X-ray |
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