A synthesis of the tetracyclic carboskeleton of isaindigotidione |
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| Authors: | Ch Yan Poon |
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| Affiliation: | Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China |
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| Abstract: | An efficient synthesis of the unique indolizino[7,6-c]quinoline carboskeleton of isaindigotidione has been achieved. This strategy employed l-proline and isatin as the main building blocks in the construction of the framework. Four transformations occurred in a one-pot operation to furnish the tetracyclic nucleus. |
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| Keywords: | Alkaloid Indolizine Quinoline |
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