A total synthesis of verbenachalcone, a bioactive diaryl ether from Verbena littoralis |
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| Authors: | Takamasa Tanabe |
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| Institution: | Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan |
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| Abstract: | Verbenachalcone 1, isolated from the aerial part of Verbena littoralis H. B. K. (Verbenaceae), has successfully been synthesized by employing anodic oxidation of the phenol derivative 3, as the key step. The bromine and chlorine substituents of 3 effected regioselective introduction of a methoxy group, as well as modulating the oxidation reaction. A flow-cell type apparatus of anodic oxidation provided the desired diaryl ether 4 in good yield. |
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| Keywords: | Verbenachalcone Anodic oxidation Verbena littoralis H B K PC12D cells Diaryl ether |
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