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Microwave-assisted efficient synthesis of spiro-fused heterocycles under solvent-free conditions |
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| Authors: | Ahmad Shaabani Ayoob Bazgir |
| Institution: | Department of Chemistry, Shahid Beheshti University, PO Box 19839-4716, Tehran, Iran |
| Abstract: | Spiro-fused heterocycles were synthesized in good to high yields by a pseudo four-component reaction of an aldehyde, urea and a cyclic β-diester or a β-diamide such as Meldrum’s acid or barbituric acid derivatives using microwave irradiation under solvent-free conditions. |
| Keywords: | Solvent free Multicomponent Microwave Biginelli reaction Spiro-fused heterocyclic rings Meldrum&rsquo s acid Barbituric acid |
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