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Novozym 435-catalyzed kinetic resolution of β-allenols. A facile route for the preparation of optically active β-allenols or allenyl acetates |
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| Authors: | Daiwang Xu Zuyi Li |
| Affiliation: | a State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, People's Republic of China b Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, People's Republic of China c State Key Laboratory of Bio-Organic & Natural Product Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, People's Republic of China |
| Abstract: | A variety of optically active β-allenols and β-allenyl acetates were synthesized via the Novozym 435-mediated kinetic resolution of racemic β-allenols. A dramatic solvent effect was observed for the stereoselectivity. The scope of the substrates and the effect of the concentration and temperature on the reaction were also investigated. |
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