Traceless synthesis of hydantoin by focused microwave irradiation |
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Authors: | Ming-Juan Lee |
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Affiliation: | Department of Chemistry, National Dong Hwa University, Shou-Feng, Hualien 974, Taiwan |
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Abstract: | An efficient, microwave-assisted method for the liquid-phase combinatorial synthesis of 1,3-disubstituted hydantoin has been developed. Chloroacetyl chloride was directly anchored to HO-PEG-OH and subsequently reacted with various primary amines in a microwave cavity. The PEG bound secondary amine coupled with isocyanates and concomitant cyclization-cleavage step occurred in mild basic conditions by microwave flash heating. The desired products were then liberated from the soluble matrix in modest yield and high purity. |
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Keywords: | Hydantoin Combinatorial chemistry Microwave irradiation Traceless synthesis |
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