Neurotoxicity of gadolinium contrast agents for magnetic resonance imaging in rats with osmotically disrupted blood-brain barrier |
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Affiliation: | 1. LINAC Division, Directorate of Technology, PINSTECH, P.O Nilore, Islamabad, Pakistan;2. Pakistan Institute of Engineering and Applied Sciences, Nilore, Islamabad, Pakistan;3. Material Division, Directorate of Technology, PINSTECH, P.O Nilore, Islamabad, Pakistan;4. Institute of Space Technology, Islamabad, Pakistan;1. Molecular Endocrinology Laboratory, Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee 247 667, Uttarakhand, India;2. University Wurzburg, Department of Anaesthesia and Critical Care, Oberduerrbacher Strasse 6, 97080 Wurzburg, Germany |
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Abstract: | The neurotoxicity of intravenously injected Gadolinium (Gd) complexes to rats with disrupted blood-brain barrier (BBB) was evaluated. After disruption of the BBB by infusion of mannitol solution, one of several contrast agents tested was injected intravenously at a dose of 1 or 3 mmol Gd/kg, and neurological symptoms were graded. The concentrations of Gd in brain and plasma were also measured. Injection of Gd-DTPA at a dose of 3 mmol Gd/kg did not change behavior. On the other hand, Gd-DTPA-BMA, Gd-DO3A-butrol, and Gd-DO3A-HP each induced behavioral impairments, and some animals died within 1 h after injection. Gd-DO3A-HP showed lethal effect even at a dose of 1 mmol/kg. The concentration of Gd in the brain of the animals injected with Gd-DO3A-HP at 3 mmol Gd/kg was essentially the same as that of animals injected with Gd-DTPA at the same dose. The neurotoxicity of the contrast agents tested was graded as follows: Gd-DTPA ≤ Gd-DTPA-BMA = Gd-DO3A-butrol < Gd-DO3A-HP. |
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