Novel applications of chloroperoxidase: enantioselective oxidation of racemic epoxyalcohols

The CPO-catalysed enantioselective oxidations of racemic glycidol and cis-2,3-epoxyhexanol to the corresponding aldehydes were studied using tert-butyl hydroperoxide in the 9:9:1 and 18:1 mixtures of hexane:ethyl acetate:buffer and hexane:buffer, respectively. Temperature and pH (100 mM citrate buffer, pH 4.0–7.0) effects on enantioselectivity in the terms of ee for the less reactive alcohol enantiomers with conversion were studied.