Baker's yeast mediated reduction of dihydroxyacetone derivatives |
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Institution: | 1. Laboratoire d''Enzymologie, UPR 9063, CNRS, 91198 Gif-sur-Yvette Cedex, France;2. Laboratoire de Chimie Physique, CNRS UMR 8000, Université Paris-Sud, Université Paris-Saclay, 91405 Orsay Cedex, France |
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Abstract: | Several monoprotected dihydroxyacetone derivatives 4a–d and their acetates 5a–d were prepared and subjected to biotransformation with baker's yeast. The simple chemical modification of the substrates (i.e. transforming the relatively small hydrophilic hydroxymethyl group into a larger hydrophobic acetoxymethyl moiety) inverted the sense of enantiotope selectivity of these reductions yielding optically active diols 6a–d, or their enantiomeric acetates (7a–d) and diols (ent-6a–d), respectively. |
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