Synthesis of optically active 3-alkoxy-6-hydroxymethyl-6-methyl-2-cyclohexenone |
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Institution: | 1. School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan;2. Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka 1000, Bangladesh |
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Abstract: | Optically active 3-alkoxy-6-hydroxymethyl-6-methyl-2-cyclohexenone and 6-acetoxymethyl-3-alkoxy-6-methyl-2-cyclohexenone were efficiently obtained by lipase-catalyzed kinetic resolution. (R)-6-Acetoxymethyl-3-(methoxymethoxy)-6-methyl-2-cyclohexenone was converted to the synthetic intermediate of cassiol. |
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