Versatile synthesis of (+)-deoxypyridinoline,a biochemical marker for diagnosis of osteoporosis |
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| Institution: | Division Organic Chemistry Research (9NM, AP20), Diagnostics Division, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6016, USA;Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioicho, Chiyoda-ku, Tokyo 102-8554, Japan;Faculty of Electrical Engineering, Shahid Beheshti University, Tehran, Iran |
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| Abstract: | A versatile chiral synthesis of the bone collagen cross-link, (+)-deoxypyridinoline (Dpd, 1) was described starting from a 3-hydroxypyridine derivative (2) via sequential introduction of three amino acid chains followed by hydrolysis. The key synthon 2, was prepared from vitamin B6 (6). |
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