Cu(ClO(4))(2)-mediated arene C-H bond halogenations of azacalixaromatics using alkali metal halides as halogen sources |
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| Authors: | Yao Bo Wang Zu-Li Zhang Hu Wang De-Xian Zhao Liang Wang Mei-Xiang |
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| Institution: | Key Laboratory for Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China. |
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| Abstract: | Regiospecific halogenation of azacalix1]arene3]pyridines at the lower rim position of the benzene ring was achieved from their cross-coupling reaction with cost-effective alkali metal halides through the Cu(ClO(4))(2)-mediated aerobic aryl C-H activation, which gave structurally well-defined aryl-Cu(III) intermediates, and a subsequent C-X bond formation reaction under very mild conditions. |
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