Combinatorial mutasynthesis of flavonoid analogues from acrylic acids in microorganisms |
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| Authors: | Chemler Joseph A Yan Yajun Leonard Effendi Koffas Mattheos A G |
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| Institution: | State University of New York at Buffalo, Department of Chemical and Biological Engineering, 303 Furnas Hall, Buffalo, NY 14260, USA. |
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| Abstract: | Flavonoids are plant secondary metabolites often used as nutraceutical supplements, but a growing number of unnatural flavonoids are being investigated as therapeutic agents. Cultures of Saccharomyces cerevisiae expressing recombinant flavonoid enzymes, including 4-coumaroyl:CoA ligase (4CL), chalcone synthase (CHS), chalcone isomerase (CHI), and flavanone 3beta-hydroxylase (FHT), produced novel flavanones and dihydroflavonols when fed with a number of aromatic acrylic acids. The flavonoid network also exhibited broad substrate specificity by converting muconic acid into a unique polypropanoid. |
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