Reversible thermal transition of polydiacetylene based on KTTKS collagen sequence |
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Authors: | Pasquale Palladino Valeria Castelletto Ashkan Dehsorkhi Dmitry Stetsenko Ian W Hamley |
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Institution: | School of Chemistry, Food and Pharmacy, University of Reading, Reading RG6 6AD, UK. I.W.Hamley@reading.ac.uk. |
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Abstract: | Here we explore the physico-chemical properties of a peptide amphiphile obtained by chemical conjugation of the collagen-stimulating peptide KTTKS with 10,12-pentacosadiynoic acid which photopolymerizes as a stable and extended polydiacetylene. We investigate the self-assembly of this new polymer and rationalize its peculiar behavior in terms of a thermal conformational transition. Surprisingly, this polymer shows a thermal transition associated with a non-cooperative increase in β-sheet content at high temperature. |
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