Trichodermatides A-D, novel polyketides from the marine-derived fungus Trichoderma reesei |
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Authors: | Sun Yi Tian Li Huang Jian Ma Hong-Yu Zheng Zhe Lv A-Li Yasukawa Ken Pei Yue-Hu |
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Institution: | School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China. |
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Abstract: | Four new polyketide derivatives, Trichodermatides A-D (1-4) were isolated from the marine-derived fungus Trichoderma reesei. Trichodermatide A (1) is an unprecedented example of a polyketide with a ketal-containing pentacyclic skeleton. The chemical structures and absolute configurations of compounds 1-4 were elucidated by extensive spectroscopic methods, especially 2D NMR and CD spectral analysis, and supported by their proposed biosynthesis pathway. The cytotoxicity of 1-4 was evaluated against A375-S2 human melanoma cell line. |
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