| Total Synthesis of N-Methylsansalvamide A |
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| 引用本文： | Shou Xin LIU Yan Lou GENG Xia TIAN Xiao Li ZHEN Jian Rong HAN. Total Synthesis of N-Methylsansalvamide A[J]. 中国化学快报, 2006, 17(6): 761-764 |
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| 作者姓名： | Shou Xin LIU Yan Lou GENG Xia TIAN Xiao Li ZHEN Jian Rong HAN |
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| 作者单位： | College of chemical ＆ pharmaceutical Engineering, Hebei University of Science ＆ Tecnnology, Shijiazhuang 050018 |
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| 基金项目： | 中国科学院资助项目;河北省自然科学基金 |
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| 摘 要： | Sansalvamide A is a cyclic depsipeptide, isolated from a marine fungus of the genus Fusarium by Belofsky in 19991. The depsipeptide displays cytotoxic and antiviral activities, and also possesses inhibitor of MCV topoisomerase2. The corresponding amide de…
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| 关 键 词： | 总合成 N-甲基氨基化合物 缩二氨酸 结构活性 抗癌活性 |
| 收稿时间： | 2005-12-14 |
Total Synthesis of N-Methylsansalvamide A |
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| Shou Xin LIU,Yan Lou GENG,Xia TIAN,Xiao Li ZHEN,Jian Rong HAN. Total Synthesis of N-Methylsansalvamide A[J]. Chinese Chemical Letters, 2006, 17(6): 761-764 |
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| Authors: | Shou Xin LIU Yan Lou GENG Xia TIAN Xiao Li ZHEN Jian Rong HAN |
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| Abstract: | Total synthesis of N-methylsansalvamide A was accomplished in solution phase by a convergent approach. An N-Boc-tri-depsipepide 6 and a dipeptide ester 10 were prepared in the yield of 89% and 91%, respectively. Cyclization of the linear penta-depsipetide was achieved with PyBOP and DIPEA in DMF-CH2Cl2. |
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| Keywords: | Synthesis N-methylsansalvamide A solution phase cyclic depsipeptide. |
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