二茂钛氨基酸配合物的合成新方法

二茂钛衍生物在催化烯烃聚合、氢化、异构化等领域具有重要应用价值1] ,同时 ,因该类衍生物还具有良好的抗癌性能 ,且其毒性远远低于顺铂类化合物2 ] ,使人们对这类配合物的研究一直非常重视 .有文献报道 3] ,以具有生物活性的配体取代二氯二茂钛中的氯原子 ,可以改善其生物利用率 ,提高二茂钛的抗癌活性 .二茂钛配合物的合成绝大多数都是在无水无氧的有机相中进行的 ,在两相(水相 /有机相 ) 4 ,5] 中则很少 .我们曾经在有机相和水相中合成了一些新的二茂钛氨基酸配合物 6] ,但操作繁杂 ,反应速度慢 ,影响因素多 ,产率低等是这两种体系…

A New Synthetic Method of Titanocene Amino Acid Complexes

Five titanocene amino acid complexes, Cp 2Ti(O 2CCH 2NHC 6H 4R) 2 (R=H, p Cl, p OC 2H 5, m CH 3, m Cl), have been prepared in a two phase system(CHCl 3/H 2O), by reacting Cp 2TiCl 2 with corresponding amino acids (RC 6H 4NHCH 2COOH ). The complexes were characterized by elemental analysis, IR and 1H NMR spectra. The results show that the carboxyl oxygen is bound to Ti to form two molecular amino acid complex and the carboxyl itself in amino acid acts as monodentate ligand. In comparison with synthesis in aqueous or anhydrolytic medium, the reaction in two phase medium appears more simply and conveniently, with yield being higher.