Non-steroidal antiinflammatory drug-copper(II) complexes: structure and biological perspectives |
| |
Authors: | Dimiza Filitsa Fountoulaki Stella Papadopoulos Athanasios N Kontogiorgis Christos A Tangoulis Vassilis Raptopoulou Catherine P Psycharis Vassilis Terzis Aris Kessissoglou Dimitris P Psomas George |
| |
Institution: | Department of General and Inorganic Chemistry, Faculty of Chemistry, Aristotle University of Thessaloniki, P.O. Box 135, GR-54124, Thessaloniki, Greece. |
| |
Abstract: | Copper(II) complexes with the non-steroidal antiinflammatory drug mefenamic acid in the presence of aqua or nitrogen donor heterocyclic ligands (2,2'-bipyridine, 1,10-phenanthroline, 2,2'-bipyridylamine or pyridine) have been synthesized and characterized. The crystal structures of (2,2'-bipyridine)bis(mefenamato)copper(II)], 2, (2,2'-bipyridylamine)bis(mefenamato)copper(II)], 4, and bis(pyridine)bis(methanol)bis(mefenamato)copper(II)], 5, have been determined by X-ray crystallography. UV study of the interaction of the complexes with calf-thymus DNA (CT DNA) has shown that the complexes can bind to CT DNA and bis(aqua)tetrakis(mefenamato)dicopper(II)] exhibits the highest binding constant to CT DNA. The cyclic voltammograms of the complexes in the presence of CT DNA solution have shown that the complexes can bind to CT DNA by the intercalative binding mode verified also by DNA solution viscosity measurements. Competitive studies with ethidium bromide (EB) indicate that the complexes can displace the DNA-bound EB suggesting strong competition with EB. Mefenamic acid and its complexes exhibit good binding propensity to human or bovine serum albumin protein having relatively high binding constant values. All the compounds have been tested for their antioxidant and free radical scavenging activity as well as for their in vitro inhibitory activity against soybean lipoxygenase showing significant activity. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|