Synthesis and biological evaluation of 2,4-diaminopteridine derivatives as nitric oxide synthase inhibitor |
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| Authors: | Fei Ma Gang Lu Wei Fen Zhou Qiu Juan Wang Yi Hua Zhang Qi Zheng Yao |
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| Affiliation: | School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | A series of novel 2,4-diamino-pteridines(9a-1)were synthesized and evaluated as inhibitors of inducible nitric oxide synthase (iNOS)in vitro.It was found that 9a,9d,9e,9h,9i and 91 showed potent inhibitory activities similar to that of methotrexate(MTX),while the activities of 9b,9c,9f,9g,9j and 9k ale stronger than MTX. |
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| Keywords: | Nitric oxide Tetrahydrobiopterin Nitric oxide synthase Synthesis Inhibitive activity |
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