|
|||||
|
|
Effect of Polyacrylamide and Dextran-Polyacrylamide Graft Polymers on Absorption and Fluorescence Spectra of Hematoporphyrin |
|
| Authors: | M Yu Losytskyy I V Madan N V Kutsevol M M Petrenko V M Yashchuk |
| Institution: | 1. Department of Physics , Taras Shevchenko National University of Kyiv , 64/13, Volodymyrs ’ka Str., 01601 , Kyiv , Ukraine;2. Department of Chemistry , Taras Shevchenko National University of Kyiv , 64/13, Volodymyrs ’ka Str., 01601 , Kyiv , Ukraine |
| Abstract: | Absorption and fluorescence spectra of hematoporphyrin (HP) solutions in distilled water and in the presence of polyacrylamide and three dextran-graft-polyacrylamide branched polymers are studied. HP is shown to interact with the studied polymers leading to the destruction of HP aggregates, which is positive for the use of porphyrin as a photosensitizer in the photodynamic therapy. For the concentrations of the polymers of 0.001%, the studied polymers demonstrated a similar impact on HP. |
| Keywords: | Hematoporphyrin aggregation graft polymers fluorescence spectra photodynamic therapy |