13C Kinetic Isotope Effect of the Pudovik Reaction |
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| Authors: | Justyna Wiktorowicz |
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| Institution: | Institute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, ?eromskiego 116, 90-924 Lodz, Poland |
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| Abstract: | Abstract13C kinetic isotope effect (KIE) was determined by means of 13C NMR for the carbonyl atom in 2-nitrobenzaldehyde in its reaction with 2H-2-oxo-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphorinane in acetonitrile at 25°C. The observed isotope effect k12/k13 = 1.0238 ± 0.0031 evidences that the formation of the P?C bond in the Pudovik reaction catalyzed by triethylamine is less advanced than the π-bond breakage of the aldehyde carbonyl group. |
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| Keywords: | Pudovik reaction kinetic isotope effects reaction mechanism NMR spectroscopy |
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