Nano-Mgo-Catalyzed One-Pot Synthesis of Phosphonate Ester Functionalized 2-Amino-3-Cyano-4H-Chromene Scaffolds at Room Temperature |
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Authors: | Goutam Brahmachari Sujay Laskar |
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Affiliation: | 1. Department of Chemistry, Laboratory of Natural Products &2. Organic Synthesis, Visva-Bharati University, Santiniketan-731 235, West Bengal, Indiabrahmg2001@yahoo.co.in brahmg2001@gmail.com goutam.brahmachari@visva-bharati-ac.in;4. Organic Synthesis, Visva-Bharati University, Santiniketan-731 235, West Bengal, India |
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Abstract: | AbstractA facile and efficient protocol for one-pot three-component synthesis of structurally diverse (2-amino-3-cyano-4H-chromen-4-yl)phosphonic acid diethyl esters from the reaction of salicylaldehydes, malononitrile (or ethyl cyanoacetate), and triethylphosphite using basic nanocrystalline MgO as catalyst in aqueous ethanolic medium at room temperature has been developed. Nano-MgO has been prepared using a simple sol-gel approach. Clean reaction profile, easy reusability of MgO nano-catalyst, mild reaction condition, good yields, and practical applicability are the major advantages of the present protocol. |
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Keywords: | Multicomponent reaction (2-amino-3-cyano-4H-chromen-4-yl)phosphonic acid diethyl esters nanocrystalline MgO room temperature |
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