Enzyme association with lipidic Langmuir-Blodgett films: interests and applications in nanobioscience |
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Authors: | Girard-Egrot Agnès P Godoy Stéphanie Blum Loïc J |
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Affiliation: | Laboratoire de Génie Enzymatique et Biomoléculaire, EMB2/UMR 5013, CNRS/UCBL, Université Claude Bernard Lyon 1, 43 Bd du 11 novembre 1918, F-69622 Villeurbanne Cedex, France. agnes.egrot@univ-lyon1.fr |
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Abstract: | This review presents the recent advances in the achievement of organized proteo-lipidic nanostructures based on Langmuir-Blodgett technology and their potential applications in the nanobioscience area. By using the self-assembled properties of amphiphilic biomolecules at the air-water interface, the Langmuir-Blodgett (LB) technique offers the possibility to prepare ultrathin layers suitable for biomolecule immobilization at the molecular level. This review will provide a general overview of the enzyme association with preformed Langmuir-Blodgett films in connection with their potential applications in biosensing device developments, and then introduce the design of a new functionalised biomimetic nanostructure with oriented recognition site. The potential applications of such an organized proteo-lipidic nanostructure for biocatalysis investigations of an immobilised enzyme in a biomimetic situation and for the development of bioelectronic devices are finally discussed. |
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