Identification of Spin Diffusion Pathways in Isotopically Labeled Biomolecules |
| |
| Authors: | Thomas R Eykyn Dominique Früh Geoffrey Bodenhausen |
| |
| Institution: | Section de Chimie, Université de Lausanne, Lausanne, 1015, Switzerland. |
| |
| Abstract: | One-dimensional NOE experiments applicable to labeled macromolecules are presented which allow the manipulation of specific spin diffusion pathways and thus unambiguously identify clandestine spins through which the direct NOE is mediated. A treatment of spin diffusion using average Liouvillian theory is shown to describe adequately these phenomena. Experiments are carried out on an 15N-labeled sample of human ubiquitin. |
| |
| Keywords: | selective NOE spin diffusion average Liouvillian theory protein NMR |
| 本文献已被 ScienceDirect 等数据库收录！ |
