A marked synergistic effect in antitumor activity of salan titanium(IV) complexes bearing two differently substituted aromatic rings |
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Authors: | Glasner Hagai Tshuva Edit Y |
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Institution: | Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, 91904 Israel. |
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Abstract: | Salan titanium(IV) complexes of differently substituted aromatic rings, where one ring is para-nitrated and another is ortho,para-halogenated, demonstrate exceptionally high anticancer activity, with IC(50) values of <1 μM, exceeding that of cisplatin by ~30-fold. Whereas an additive effect in hydrolytic stability was detected for these highly stable complexes, an unexpected synergistic effect in anticancer activity makes these hybrid complexes substantially more active than both their symmetrical analogues alone and their equimolar mixture. |
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