| PEG/PEI/PASP修饰的磁性氧化铁纳米粒子的制备及磁共振成像的研究 |
| |
| 引用本文： | 钟良,谢松伯,夏天,杨凤丹,聂婉,梁广钦,张宝林.PEG/PEI/PASP修饰的磁性氧化铁纳米粒子的制备及磁共振成像的研究[J].人工晶体学报,2019,48(8):1549-1556. |
| |
| 作者姓名： | 钟良 谢松伯 夏天 杨凤丹 聂婉 梁广钦 张宝林 |
| |
| 作者单位： | 桂林理工大学材料科学与工程学院, 广西有色金属及特色材料加工教育部重点实验室,广西光电材料与器件重点实验室,桂林 541004 |
| |
| 基金项目： | 国家自然科学基金(51562007) |
| |
| 摘 要： | 以聚乙二醇(Polyethylene glycol,PEG)为溶剂及反应剂,聚乙烯亚胺(Polyethyleneimine,PEI)为添加剂,乙酰丙酮铁(Fe(acac) 3 )为铁源,采用高温热分解法制备了超顺磁性氧化铁纳米粒子(Super-paramagnetic iron oxide nanoparticles,SPIONs)。通过物理法将聚天冬氨酸(Poly aspartic acid,PASP)成功修饰在PEG、PEI修饰的超顺磁性氧化铁纳米粒子(PEG/PEI-SPIONs)表面,得到PEG/PEI/PASP-SPIONs。透射电子显微镜表征结果显示,PEG/PEI/PASP-SPIONs具有良好的分散性,且平均粒径为(10.8±2.0) nm(平均值±标准差)。小鼠脑部磁共振成像实验表明,PEG/PEI/PASP-SPIONs可以长时间在小鼠脑部呈现磁共振成像(MRI)效果,PEG/PEI/PASP-SPIONs在小鼠脑部的成像时间比PEG/PEI-SPIONs和PEG/PEI/Tween 80-SPIONs的成像时间更短,可用于磁共振成像的造影剂。
|
| 关 键 词： | SPIONs超顺磁性氧化铁纳米粒子 聚天冬氨酸 MRI 造影剂 |
Preparation and Magnetic Resonance Imaging of Magnetic Iron Oxide Nanoparticles Modified by PEG/PEI/PASP |
| |
| ZHONG Liang,XIE Song-bo,XIA Tian,YANG Feng-dan,NIE Wan,LIANG Guang-qin,ZHANG Bao-lin.Preparation and Magnetic Resonance Imaging of Magnetic Iron Oxide Nanoparticles Modified by PEG/PEI/PASP[J].Journal of Synthetic Crystals,2019,48(8):1549-1556. |
| |
| Authors: | ZHONG Liang XIE Song-bo XIA Tian YANG Feng-dan NIE Wan LIANG Guang-qin ZHANG Bao-lin |
| |
| Institution: | (Guangxi Key Laboratory of Optoelectronic Materials and Devices,State Key Laboratory Breeding Base of Nonferrous Metals andSpecific Materials Processing,School of Materials Science and Engineering,Guilin University of Technology,Guilin 541004,China) |
| |
| Abstract: | Polyethylene glycol (PEG) was used as solvent and reagent, polyethyleneimine (PEI) was used as additive, iron (III) acetylacetonate (Fe(acac) 3 ) was used as iron source, and super-paramagnetic iron oxide nanoparticles (SPIONs) were prepared by high temperature thermal decomposition method. PEG/PEI/PASP-SPIONs were obtained by successfully modifying poly aspartic acid (PASP) on PEG and PEI coated SPIONs (PEG/PEI-SPIONs). Transmission electron microscopy (TEM) shows that PEG/PEI/ PASP-SPIONs have good dispersion and the average particle size was ( 10.8±2.0 )nm. Magnetic resonance imaging (MRI) of mouse brain show that PEG/PEI/PASP-SPIONs have MRI longer contrast effect in the brain of mice. The imaging time of PEG/PEI/PASP-SPIONs in the brain of mice was shorter than that of PEG/PEI-SPIONs and PEG/PEI/Tween 80-SPIONs. PEG/PEI/PASP-SPIONs can be used as MRI contrast agent. |
| |
| Keywords: | superparamagnetic iron oxide nanoparticles (SPIONs) polyaspartic acid MRI contrast agent |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《人工晶体学报》浏览原始摘要信息 |
| 点击此处可从《人工晶体学报》下载免费的PDF全文 |
|
