Extending the dynamic range of electrochemical sensors using multiple modified electrodes |
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Authors: | Edith Chow Elicia L S Wong Owen Pascoe D Brynn Hibbert J Justin Gooding |
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Institution: | (1) School of Chemistry, The University of New South Wales, Sydney, NSW, 2052, Australia |
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Abstract: | Multiple electrodes, combined with a chemometric strategy to calibrate the measurement response, have been used for the determination
of an analyte across a broader dynamic range than is possible with a single electrode. The model system used for the detection
of copper comprised electrodes modified with a self-assembled monolayer. The electrodes were modified with the copper-complexing
species (3-mercaptopropionic acid, thioctic acid, and the peptides cysteine and Gly-Gly-His) and copper was determined over
concentrations ranging from nanomolar to millimolar using voltammetric analysis. We have demonstrated that by combining the
calibration functions from the four electrodes a better estimate (i.e. with smaller variance) of the concentration of the
analyte is obtained. Measurement uncertainty is expressed for independently prepared electrodes, which allows the possibility
of commercial production and factory calibration. The principles of using multiple electrodes modified with recognition elements
with different affinities for the target analyte to extend the dynamic range of sensors is a general one that could be applied
to other analytes. |
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Keywords: | Metal detection Peptides Biosensors Electrochemistry Electrode arrays |
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