| Two Series of Synthetic Territrem B Analogues and their Biological Activities |
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| 作者姓名： | FengZHAO JinHaoZHAO HaiBoLI LeiXiangYANG HuaBAI YanGuangWANG ShoeiShengLEE YuZHAO |
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| 作者单位： | [1]DepartmentofTraditionalChineseMedicineandNaturalDrugResearch,CollegeofPharmaceuticalSciences,ZhejiangUniversity,Hangzhou310031 [2]DepartmentofChemistry,CollegeofSciences,ZhejiangUniversity,Hangzhou310027 [3]ZhejiangHisunNaturelitePharmaceuticalR＆DCo.,Ltd.,Hangzhou310007 [4]DepartmentofPharmacy,CollegeofMedicine,NationalTalwanUniversity,Talpei10018 [5]DepartmentofTraditionalChineseMedicineandNaturalDrugResearch,CollegeofPharmaceuticalSciences,ZhejiangUniversity,Hangzhou310031／／DepartmentofChemistry,CollegeofSciences,Zhejiang＂Uni-vers-ity,Hangzhou310027 |
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| 摘 要： | Two series of territrem B analogues (6, 11) were designed and synthesized from jujubogenin 2. Compound llc inhibited AChE with the ratio of 70% at 10^-4 mol/L. Compounds5a, 5b, 6a and lib showed moderate cytotoxicity on cultured KB cells at 10^-6 mol]L.Compounds 5c and 6b alleviated injury arising from oxygen-glucose deprivation (OGD).
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| 关 键 词： | 合成方法 生物活性 化学结构 阿耳茨海默病 早老性痴呆 药物 细胞 |
Two Series of Synthetic Territrem B Analogues and their Biological Activities |
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| FengZHAO JinHaoZHAO HaiBoLI LeiXiangYANG HuaBAI YanGuangWANG ShoeiShengLEE YuZHAO.Two Series of Synthetic Territrem B Analogues and their Biological Activities[J].Chinese Chemical Letters,2005,16(4):457-460. |
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| Abstract: | Two series of territrem B analogues (6, 11) were designed and synthesized from jujubogenin 2. Compound 11c inhibited AChE with the ratio of 70% at 10-4 mol/L. Compounds 5a, 5b, 6a and 11b showed moderate cytotoxicity on cultured KB cells at 10-6 mol/L. Compounds 5c and 6b alleviated injury arising from oxygen-glucose deprivation (OGD). |
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| Keywords: | Territrem B analogues acetylcholinesterase (AChE) inhibitor cytotoxicity on KB cells oxygen-glucose deprivation (OGD) |
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