Influence of the Structure of Steroid Hormones on Their Association with Cyclodextrins: A High-Performance Liquid Chromatography Study
Authors:
Nina Sadlej-Sosnowska
Affiliation:
(1) Drug Institute, Chelmska 30/34, 00-725 Warsaw, Poland
Abstract:
The association constants of fourteen steroid hormones with - and -cyclodextrin were measured in methanol-water (20 : 80 v/v) at 35 °C using the chromatographic Hummel-Dreyer method. It was found that the greatest influence on the association constants is the structural features of ring A of these compounds but the substituents of ring D also alter the complex stability to an appreciable degree. The measured association constants were considerably greater than the corresponding values measured previously in the medium containing more methanol (45 instead of 20%).