Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake |
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| Authors: | Hideo Makimura Tooru M Mizuno Jason W Mastaitis Reuven Agami Charles V Mobbs |
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| Affiliation: | (1) Fishberg Center for Neurobiology, Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1639, 10029 New York, New York, USA;(2) Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, One Gustave L. Levy Place, 10029 New York, New York, USA;(3) Division of Tumor Biology, The Netherlands Cancer Institute, 121 Plesmanlaan, 1066 Amsterdam, CX, The Netherlands |
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| Abstract: | Background Several lines of evidence strongly suggest that agouti-related peptide (AGRP) plays a key role in the regulation of metabolic function but ablation of the AGRP gene has no apparent effect on metabolic function. Since specific pharmacological antagonists of AGRP do not presently exist, we assessed if reduction of hypothalamic AGRP mRNA by RNA interference (RNAI) would influence metabolic function, an outcome suggesting that pharmacological antagonists might constitute useful reagents to treat obesity. |
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