The hydrogen‐bonding network in deacetyl­cephalothin

The structural analysis of deacetyl­cephalothin systematic name: (6R,7R)‐3‐hydroxy­methyl‐8‐oxo‐7‐(2‐thio­phen‐2‐yl­acetyl­amino)‐5‐thia‐1‐aza­bicyclo­4.2.0]oct‐2‐ene‐2‐carboxylic acid], C₁₄H₁₄N₂O₅S₂, shows that the geometry of the central bicyclic moiety is close to the geometry exhibited by other biologically active cephalosporin antibiotics. The mol­ecules are arranged in a helical chain running parallel to the 2₁ axis via a strong O—H?O hydrogen bond. The main helices are zipped together via N—H?O inter­actions, forming infinite layers. The supramolecular architecture is stabilized by O—H?S and C—H?O hydrogen bonds.