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Stavudine
Authors:Mahmoud Mirmehrabi  Sohrab Rohani  Michael C Jennings
Abstract:The crystal structure of the title compound (systematic name: 2′,3′‐didehydro‐2′,3′‐deoxy­thymidine), C10H12N2O4, consists of two mol­ecules in the asymmetric unit bound together by hydrogen bonds. The conformational geometry differentiates this form of stavudine from its two previously published polymorphs. In addition, a different hydrogen‐bonding scheme is observed compared with the previous two structures. This polymorph is the thermodynamically most stable form of the anti­viral drug, as evidenced by differential scanning calorimetry (DSC) and IR data.
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