Cyclo(l‐leucyl‐α,β‐dehydrophenylalanine): the first diketopiperazine containing an α,β‐dehydrophenylalanine residue |
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Authors: | A. Bagaria S. Ramakumar M. Gupta V. S. Chauhan |
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Abstract: | The title compound (systematic name: 3‐benzylidene‐6‐isobutylpiperazine‐2,5‐dione), C15H18N2O2, an α,β‐dehydrophenylalanine containing diketopiperazine, crystallizes in the space group P1 with two molecules in the asymmetric unit arranged antiparallel to one another. The α,β‐dehydrophenylalanine (ΔPhe) residue in this cyclic peptide retains its planarity but deviates from the standard conformations observed in its linear analogues. Each type of molecule forms a linear chain with molecules of the same type via pairwise N—H⋯O hydrogen bonds, while weaker C—H⋯O interactions link the chains together to form a three‐dimensional network. |
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