Triazabicyclodecene: an effective isotope exchange catalyst in CDCl(3) |
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| Authors: | Sabot Cyrille Kumar Kanduluru Ananda Antheaume Cyril Mioskowski Charles |
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| Institution: | Laboratoire de Synthèse Bio-Organique, UMR 7175/LC1-CNRS, Université Louis Pasteur de Strasbourg, B.P. 60024, 67401 Illkirch cedex, France. |
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| Abstract: | We describe the first effective H/D exchange reaction with acidic substrates in CDCl(3) at room temperature. The particularly mild reaction conditions involved (solvent, base, and temperature) allow the chemoselective deuteration of ketones over esters. An NMR study was conducted with the aim of rationalizing the results obtained in the presence of TBD as catalyst. |
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