| Hirsutellide A立体异构体的单晶结构与抗分支杆菌生物活性研究 |
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| 引用本文： | 许艳杰,李江胜,颜范勇,陈立功. Hirsutellide A立体异构体的单晶结构与抗分支杆菌生物活性研究[J]. 有机化学, 2007, 27(11): 1366-1368 |
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| 作者姓名： | 许艳杰 李江胜 颜范勇 陈立功 |
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| 作者单位： | 1. 天津大学化工学院,天津,300072
2. 天津大学药物科学与技术学院,天津,300072 |
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| 摘 要： | 研究了hirsutellide A立体异构体的X衍射单晶结构及其抗分支杆菌活性. 该化合物具有扭曲马鞍型18元大环结构; 在体外生物活性测试中, 化合物未表现出明显的抗分支杆菌活性. 由实验结果可以看出在天然环酯肽hirsutellide A中3'-C手性中心是其生物活性关键位点之一.
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| 关 键 词： | hirsutellide A 单晶结构 生物活性 抗分支杆菌 环六酯肽 |
| 收稿时间： | 2007-01-24 |
| 修稿时间： | 2007-01-24 |
Study on X-ray Crystallography and Antimycobacterial Bioactivity of the Stereoisomer of Hirsutellide A |
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| XU, Yan-Jie,LI, Jiang-Sheng,YAN, Fan-Yong,CHEN, Li-Gong. Study on X-ray Crystallography and Antimycobacterial Bioactivity of the Stereoisomer of Hirsutellide A[J]. Chinese Journal of Organic Chemistry, 2007, 27(11): 1366-1368 |
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| Authors: | XU Yan-Jie LI Jiang-Sheng YAN Fan-Yong CHEN Li-Gong |
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| Affiliation: | 1. School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072;2. School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072 |
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| Abstract: | X-ray crystallography and antimycobacterial activity of a cyclohexadepsipeptide, one of the stereoisomers of hirsutellide A, were studied. Its single crystal structure reveals that the 18 membered mac-rocycle has a distorted saddle shape. The cyclopeptide exhibited no significant antimycobacterial activity in vitro. It was concluded that the chiral center of 3'-C was one of the pivotal factor in hirsutellide A for its biological activity. |
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| Keywords: | hirsutellide A |
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