1-Amino-3,3-difluorocyclobutanecarboxylic acid |
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Authors: | Pavel K Mykhailiuk Dmytro S Radchenko Igor V Komarov |
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Institution: | a Department of Chemistry, Kyiv National Taras Shevchenko University, Volodymyrska Street, 64, Kyiv 01033, Ukraine b Enamine Ltd., Oleksandra Matrosova Street, 23, Kyiv 01103, Ukraine |
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Abstract: | A new fluorinated analogue of 1-aminocyclobutane-1-carboxylate (ACBC) - 1-amino-3,3-difluorocyclobutanecarboxylic acid (6) - has been synthesized in six steps from acetone. The key step of the synthesis is a transformation of a ketone group into the CF2-group using morpholino-sulphur trifluoride. |
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Keywords: | Fluorine Amino acids Cyclobutane |
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