Synthesis and anti-microbial activity of some new fluorinated 1H-pyrazoles |
| |
| Authors: | Dun-Jia Wang Ling Fan Chun-Yang Zheng Zheng-Dong Fang |
| |
| Institution: | Department of Chemistry and Environmental Engineering, Hubei Normal University, Huangshi 435002, PR China |
| |
| Abstract: | Several new trifluoromethyl-1H-pyrazoles were prepared by reaction of hydrazine monohydrate with 1,3-diketones. Their structures were confirmed by elemental analysis, IR, 1H NMR and EI-MS spectroscopy. The anti-microbial activities of the newly synthesized compounds were examined by disc diffusion method against Escherichia coli, Staphylococcus aureus, Pyricularia oryzae and Rhizoctnia solani. All the trifluoromethyl-1H-pyrazoles exhibited a certain degree of anti-bacterial and anti-fungal activities. |
| |
| Keywords: | Trifluoromethyl-1H-pyrazole Synthesis 1 3-Diketones Anti-microbial activity |
| 本文献已被 ScienceDirect 等数据库收录！ |
