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An efficient, recoverable fluorous organocatalyst for direct reductive amination of aldehydes |
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| Authors: | Yi-Bo Huang Wen-Bin Yi |
| Institution: | a School of Chemical Engineering, Nanjing University of Science & Technology, Xiao Ling Wei Street, No. 200, Nanjing 210094, Jiangsu, China b Department of Pharmacy, Changzhou Institute of Engineering Technology, Changzhou 213164, China |
| Abstract: | A commercially available perfluorooctyl aniline and phenyl isothiocyanate were reacted under mild conditions to give 1-4-(perfluorooctyl)phenyl]-3-phenylthiourea as an analogue of thiourea-based organocatalyst. This fluorous organocatalyst was successfully employed to direct reductive amination of aldehydes. It could be readily separated from reaction product by fluorous solid phase extraction for direct use. |
| Keywords: | Thiourea Fluorous organocatalyst Reductive amination Fluorous solid phase extraction (F-SPE) |
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