Synthesis and antimicrobial activity of some novel 2-(substituted fluorobenzoylimino)-3-(substituted fluorophenyl)-4-methyl-1,3-thiazolines |
| |
Authors: | Aamer Saeed Uzma Shaheen Faiza Kazmi |
| |
Affiliation: | a Department of Chemistry, Quaid-I-Azam University, Islamabad 45320, Pakistan b Department of Microbiology, Quaid-I-Azam University, Islamabad 45320, Pakistan |
| |
Abstract: | The synthesis of several 2-(substituted fluorobenzoylimino)-3-(substituted fluorophenyl)-4-methyl-1,3-thiazolines (2a-t) was carried out by base-catalyzed cyclization of corresponding 1-(fluorobenzoyl)-3-(fluorophenyl)thioureas (1a-t) with 2-bromoacetone in aqueous medium. The structures of the synthesized compounds were confirmed by spectral and elemental analysis. All synthesized compounds were evaluated for in vitro antibacterial activity using Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa). The minimum inhibitory concentration (MIC) was determined for the most active compounds. In vitro antifungal activity was also determined against the five fungal species (Rhizopus oryzae, Fusarium oxysporum, Aspergillus terreus, A. niger and A. fumigatus). |
| |
Keywords: | Antimicrobial activity Fluorinated imino-1 3-Thiazolines Fluorinated 1,3-disubstituted thioureas |
本文献已被 ScienceDirect 等数据库收录! |
|