Concept of Absolute Enantioselective Separation |
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Authors: | Roman Bielski Michal Tencer |
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Institution: | a Value Recovery, Inc., 510 Heron Drive, Suite 301, Bridgeport, NJ 08014, USA b University of Ottawa, School of Information Technology and Engineering, Ottawa, 800 King Edward Av., ON, K1N 6N5 Canada c MST Consulting, Ottawa, ON, Canada |
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Abstract: | A novel approach to separations of racemates is described. It is a chromatography-like process in which molecules to be separated are oriented in two directions perpendicular to each other and parallel to the surface. If this requirement is met the opposite enantiomers differ in the energy of interaction with the surface. We call the process Absolute Enantioselective Separation (AES). Surface requirements for resolving a racemate to enantiomers are discussed. AES can be accomplished either by interaction of racemate components with a repeating pattern on the not necessarily chiral surface and interaction with a static electric field or by interaction with two repeating patterns defining the chirality of the surface. Additionally, a multiple use of electric fields to enable a separation in bulk is described. The ease of separation of selected natural compounds (amino acids and monosaccharides) in the AES process is also discussed. |
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Keywords: | Racemate Separation Absolute Homochirality Chiral surface |
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