A facile and efficient synthesis of β-amino alcohols using 2,2,2-trifluoroethanol as a metal-free and reusable medium |
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| Authors: | Samad Khaksar Mahmood Tajbakhsh |
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| Institution: | a Chemistry Department, Tarbiat Modares University, P.O. Box 14155-4838, Tehran, Iran
b Chemistry Department, Mazandaran University, Babol Sar, Iran |
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| Abstract: | Trifluoroethanol was used as a reusable catalyst and medium for the ring opening of epoxides using aliphatic and aromatic amines as nucleophile under mild conditions to give the corresponding β-amino alcohols in high yields and regioselectivity. |
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| Keywords: | β-Amino alcohols Regioselectivity TFE Hydrogen bonding |
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