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Interaction of hexafluorosilicic acid with sulfa drugs. Bis(sulfathiazolium) hexafluorosilicate: Spectral data and crystal structure |
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| Authors: | Vladimir O. Gelmboldt Marina S. Fonari |
| Affiliation: | a Odessa State Medical University of Ministry of Health of Ukraine, Valikhovskiy lane, 2, 65026, Odessa, Ukraine b Odessa State Environmental University of Ministry of Education and Science of Ukraine, Lvovskaya str., 15, 65016, Odessa, Ukraine c Physico-Chemical Institute of Environment and Human Protection of Ministry of Education and Science of Ukraine and National Academy of Sciences of Ukraine, Preobrazhenskaya str., 3, 65082, Odessa, Ukraine d Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Technion City, 32000 Haifa, Israel e Institute of Applied Physics, Academy of Sciences of Moldova, Academy str., 5, MD2028 Chisinau, Republic of Moldova |
| Abstract: | Interaction of hexafluorosilicic acid with sulfa drugs sulfathiazole (stz) and sulfalen (2-sulfanilamido-3-methoxypyrazine, sl) results in the crystalline salts of the compositions [stzH]2[SiF6] (I) and [4-H2NO2SPhNH3]2[SiF6] (II). Complex I is characterized by IR, mass spectrometry data and single crystal X-ray diffraction. The crystal structure of I is stabilized by a network of charge-assisted hydrogen bonding. The relationship between the solubility and H-bonding system in I, II and related “onium” hexafluorosilicates is discussed. The formation of complex II, previously reported as an interaction product of hexafluorosilicic acid with 4-aminobenzenesulfonamide (sulfanilamide), is the result of cleavage of the C-N bond in sulfalen in acidic medium. |
| Keywords: | Hexafluorosilicate Sulfa drugs Solubility Hydrogen bonding Crystal structure |
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